GABAA receptor and LGI1 antibody encephalitis in a patient with thymoma
نویسندگان
چکیده
Autoimmune encephalitis related to antibodies against neuronal cell surface and synaptic proteins is a new category of disorders in which the targets are well-known proteins and receptors involved in synaptic transmission and neuronal excitability. GABAA receptor is one of the latest identified antigens within this category. Hightiter serum and CSF GABAA receptor antibodies were recently reported in 6 patients with autoimmune encephalitis associated with seizures or status epilepticus, 4 of them requiring pharmacologic-induced coma. Patients’ brainMRIs showed characteristic multiple cortical and subcortical abnormalities with fluid-attenuated inversion recovery (FLAIR)/T2 hyperintensity. Antibodies to LGI1 are associated with limbic encephalitis previously attributed to voltage-gated potassium channels (VGKC). Coexistence of these antibodies is rare and intriguing. We report here the presence of antibodies to the GABAA receptor and LGI1 in a patient with autoimmune encephalitis and thymoma.
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